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“Making’ - a hands-on practice of creating technology-based artifacts typically involves integrating electronics, programming, or 3D printing. This paper describes the targeted infusion of “making” into undergraduate STEM education as an approach to encourage innovation while building capacity in the 21st-century technical STEM skills of engineering and design. “Making’ has the potential to impact self-efficacy and building capacity in technical STEM skills among underrepresented and underserved science majors. To investigate how “making” experiences are received by Underrepresented Minority (URM) students at an Historically Black College or University (HBCU), we applied and received funding through the National Science Foundation HBCU-UP Targeted Infusion Project (TIP) mechanism. The infusion included “making” instructional practices and Course-based Undergraduate Research Experiences (CUREs) into two undergraduate biology courses. Assessment data indicates the targeted - infusion courses were well-received by these communities with females exceling in iteration and communication of engineered designs.